The synergy of terpenes and cannabinoids is the Entourage Effect. The combination is greater than the sum of the individual compounds. Pioneering Israeli researchers Shimon Ben-Shabat and Raphael Mechoulam first articulated the synergy of cannabinoids and terpenes in 1998. Working together, the compounds in cannabis complement one another like the human endocannabinoid system. The entourage effect is responsible for many of the therapeutic benefits in cannabis and in Doctor Terpene formulations.