GENE NAME (BOLD) / SYNONYMS:
MYDGF / C19orf10 IL25
ENCODED PROTEIN NAME:
Myeloid-derived growth factor (UniProt: http://www.uniprot.org/uniprot/Q969H8)
Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518).
Protein Sequence (173aa):
Gene Coding Sequence:
For the MYDGF DNA coding sequence will be used as the template for synthesis of the MYDGF mimetic, please send request to PhaRNA customer service: firstname.lastname@example.org a> em>