GENE NAME (BOLD) / SYNONYMS:
IL34 / C16orf77
ENCODED PROTEIN NAME:
Interleukin-34 (UniProt: http://www.uniprot.org/uniprot/Q6ZMJ4)
Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1.
Protein Sequence (242aa):
Gene Coding Sequence:
For the IL34 DNA coding sequence will be used as the template for synthesis of the IL34 mimetic, please send request to PhaRNA customer service: firstname.lastname@example.org a> em>