GENE NAME (BOLD) / SYNONYMS:
IL33 / C9orf26 IL1F11 NFHEV
ENCODED PROTEIN NAME:
Interleukin-33 (UniProt: http://www.uniprot.org/uniprot/O95760)
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an “alarmin”, that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation (PubMed:18787100).
Protein Sequence (270aa):
Gene Coding Sequence:
For the IL33 DNA coding sequence will be used as the template for synthesis of the IL33 mimetic, please send request to PhaRNA customer service: email@example.com a> em>