GENE NAME (BOLD) / SYNONYMS:
IL26 / AK155
ENCODED PROTEIN NAME:
Interleukin-26 (UniProt: http://www.uniprot.org/uniprot/Q9NPH9)
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
Protein Sequence (171aa):
Gene Coding Sequence:
For the IL26 DNA coding sequence will be used as the template for synthesis of the IL26 mimetic, please send request to PhaRNA customer service: firstname.lastname@example.org a> em>