GENE NAME (BOLD) / SYNONYMS:
ENCODED PROTEIN NAME:
Interleukin-21 (UniProt: http://www.uniprot.org/uniprot/Q9HBE4)
Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (By similarity). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.
Protein Sequence (155aa):
Gene Coding Sequence:
For the IL21 DNA coding sequence will be used as the template for synthesis of the IL21 mimetic, please send request to PhaRNA customer service: firstname.lastname@example.org a> em>