GENE NAME (BOLD) / SYNONYMS:
IL12B / NKSF2
ENCODED PROTEIN NAME:
Interleukin-12 subunit beta (UniProt: http://www.uniprot.org/uniprot/P29460)
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Protein Sequence (328aa):
Gene Coding Sequence:
For the IL12B DNA coding sequence will be used as the template for synthesis of the IL12B mimetic, please send request to PhaRNA customer service: firstname.lastname@example.org a> em>