GENE NAME (BOLD) / SYNONYMS:
ENCODED PROTEIN NAME:
Interleukin-11 (UniProt: http://www.uniprot.org/uniprot/P20809)
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation (PubMed:12919066). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3.
Protein Sequence (199aa):
Gene Coding Sequence:
For the IL11 DNA coding sequence will be used as the template for synthesis of the IL11 mimetic, please send request to PhaRNA customer service: firstname.lastname@example.org a> em>