GENE NAME (BOLD) / SYNONYMS:
IFNL3 / IL28B IL28C ZCYTO22
ENCODED PROTEIN NAME:
Interferon lambda-3 (UniProt: http://www.uniprot.org/uniprot/Q8IZI9)
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Protein Sequence (196aa):
Gene Coding Sequence:
For the IFNL3 DNA coding sequence will be used as the template for synthesis of the IFNL3 mimetic, please send request to PhaRNA customer service: firstname.lastname@example.org a> em>