GENE NAME (BOLD) / SYNONYMS:
IFNL1 / IL29 ZCYTO21
ENCODED PROTEIN NAME:
Interferon lambda-1 (UniProt: http://www.uniprot.org/uniprot/Q8IU54)
Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.
Protein Sequence (200aa):
Gene Coding Sequence:
For the IFNL1 DNA coding sequence will be used as the template for synthesis of the IFNL1 mimetic, please send request to PhaRNA customer service: email@example.com a> em>